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treatment with sis3  (TargetMol)


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    Structured Review

    TargetMol treatment with sis3
    Flow diagram of this study. PCD, Programmed cell death; Dox, Doxrubicin; Ara-C, Cytarabine; <t>SIS3,</t> SAMD3 inhibitor; P-SMAD3, phosphorylated SMAD3
    Treatment With Sis3, supplied by TargetMol, used in various techniques. Bioz Stars score: 93/100, based on 5 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/treatment+with+sis3/pmc11830216-114-1-9?v=TargetMol
    Average 93 stars, based on 5 article reviews
    treatment with sis3 - by Bioz Stars, 2026-07
    93/100 stars

    Images

    1) Product Images from "Machine learning-based bulk RNA analysis reveals a prognostic signature of 13 cell death patterns and potential therapeutic target of SMAD3 in acute myeloid leukemia"

    Article Title: Machine learning-based bulk RNA analysis reveals a prognostic signature of 13 cell death patterns and potential therapeutic target of SMAD3 in acute myeloid leukemia

    Journal: BMC Cancer

    doi: 10.1186/s12885-025-13658-3

    Flow diagram of this study. PCD, Programmed cell death; Dox, Doxrubicin; Ara-C, Cytarabine; SIS3, SAMD3 inhibitor; P-SMAD3, phosphorylated SMAD3
    Figure Legend Snippet: Flow diagram of this study. PCD, Programmed cell death; Dox, Doxrubicin; Ara-C, Cytarabine; SIS3, SAMD3 inhibitor; P-SMAD3, phosphorylated SMAD3

    Techniques Used:

    The level of phosphorylated-SMAD3/SMAD3 and drug sensitivity-related programmed cell death in AML cell strains. ( A ) The corresponding genotypes of different AML cell lines. ( B - C ) The expression levels of SMAD3 and its phosphorylated form (P-SMAD3) in different AML cell lines were detected by western blotting. ( D - F ) Survival analysis of AML cell lines treated with the SMAD3 inhibitor SIS3, traditional chemotherapeutic drugs (doxorubicin plus Ara-C), or their combination. The optical density (OD) value at 450 nm was via a microplate reader, and the OD value was proportional to the cell viability. (G-H) PCD-related molecular markers in drug-treated (SIS3, DOX + Ara-c, DOX + Ara-c + SIS3) MV4-11 and THP-1 cell lines were detected via western blotting
    Figure Legend Snippet: The level of phosphorylated-SMAD3/SMAD3 and drug sensitivity-related programmed cell death in AML cell strains. ( A ) The corresponding genotypes of different AML cell lines. ( B - C ) The expression levels of SMAD3 and its phosphorylated form (P-SMAD3) in different AML cell lines were detected by western blotting. ( D - F ) Survival analysis of AML cell lines treated with the SMAD3 inhibitor SIS3, traditional chemotherapeutic drugs (doxorubicin plus Ara-C), or their combination. The optical density (OD) value at 450 nm was via a microplate reader, and the OD value was proportional to the cell viability. (G-H) PCD-related molecular markers in drug-treated (SIS3, DOX + Ara-c, DOX + Ara-c + SIS3) MV4-11 and THP-1 cell lines were detected via western blotting

    Techniques Used: Expressing, Western Blot



    Similar Products

    treatment with sis3  (TargetMol)
    93
    TargetMol treatment with sis3
    Flow diagram of this study. PCD, Programmed cell death; Dox, Doxrubicin; Ara-C, Cytarabine; <t>SIS3,</t> SAMD3 inhibitor; P-SMAD3, phosphorylated SMAD3
    Treatment With Sis3, supplied by TargetMol, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/treatment+with+sis3/pmc11830216-114-1-9?v=TargetMol
    Average 93 stars, based on 1 article reviews
    treatment with sis3 - by Bioz Stars, 2026-07
    93/100 stars
    		  Buy from Supplier

    Image Search Results


    Flow diagram of this study. PCD, Programmed cell death; Dox, Doxrubicin; Ara-C, Cytarabine; SIS3, SAMD3 inhibitor; P-SMAD3, phosphorylated SMAD3

    Journal: BMC Cancer

    Article Title: Machine learning-based bulk RNA analysis reveals a prognostic signature of 13 cell death patterns and potential therapeutic target of SMAD3 in acute myeloid leukemia

    doi: 10.1186/s12885-025-13658-3

    Figure Lengend Snippet: Flow diagram of this study. PCD, Programmed cell death; Dox, Doxrubicin; Ara-C, Cytarabine; SIS3, SAMD3 inhibitor; P-SMAD3, phosphorylated SMAD3

    Article Snippet: After treatment with SIS3 (0, 10 µM) (T3636, 521984-48-5, TargetMol, China), doxorubicin (70 nM) (T1456, 23214-92-8, Target Mol, China), or cytarabine (Ara-c, 1 µM) (T1272, 147-94-4, Target Mol, China) at 37 °C for 72 h, the cells were incubated with 10 µL of CCK-8 reagent (WK464, Dojindo, JAP) for 2 h at 37 °C.

    Techniques:

    The level of phosphorylated-SMAD3/SMAD3 and drug sensitivity-related programmed cell death in AML cell strains. ( A ) The corresponding genotypes of different AML cell lines. ( B - C ) The expression levels of SMAD3 and its phosphorylated form (P-SMAD3) in different AML cell lines were detected by western blotting. ( D - F ) Survival analysis of AML cell lines treated with the SMAD3 inhibitor SIS3, traditional chemotherapeutic drugs (doxorubicin plus Ara-C), or their combination. The optical density (OD) value at 450 nm was via a microplate reader, and the OD value was proportional to the cell viability. (G-H) PCD-related molecular markers in drug-treated (SIS3, DOX + Ara-c, DOX + Ara-c + SIS3) MV4-11 and THP-1 cell lines were detected via western blotting

    Journal: BMC Cancer

    Article Title: Machine learning-based bulk RNA analysis reveals a prognostic signature of 13 cell death patterns and potential therapeutic target of SMAD3 in acute myeloid leukemia

    doi: 10.1186/s12885-025-13658-3

    Figure Lengend Snippet: The level of phosphorylated-SMAD3/SMAD3 and drug sensitivity-related programmed cell death in AML cell strains. ( A ) The corresponding genotypes of different AML cell lines. ( B - C ) The expression levels of SMAD3 and its phosphorylated form (P-SMAD3) in different AML cell lines were detected by western blotting. ( D - F ) Survival analysis of AML cell lines treated with the SMAD3 inhibitor SIS3, traditional chemotherapeutic drugs (doxorubicin plus Ara-C), or their combination. The optical density (OD) value at 450 nm was via a microplate reader, and the OD value was proportional to the cell viability. (G-H) PCD-related molecular markers in drug-treated (SIS3, DOX + Ara-c, DOX + Ara-c + SIS3) MV4-11 and THP-1 cell lines were detected via western blotting

    Article Snippet: After treatment with SIS3 (0, 10 µM) (T3636, 521984-48-5, TargetMol, China), doxorubicin (70 nM) (T1456, 23214-92-8, Target Mol, China), or cytarabine (Ara-c, 1 µM) (T1272, 147-94-4, Target Mol, China) at 37 °C for 72 h, the cells were incubated with 10 µL of CCK-8 reagent (WK464, Dojindo, JAP) for 2 h at 37 °C.

    Techniques: Expressing, Western Blot